Parkinsonism Occurring with Methyldopa Treatment

Methyldopa in the Treatment of Hypertension.

S ISCE t,he initial comm~~ni~ation of Oates etall reporting that methyldopa lowered blood pressure in hypertensive patients additional studies hal-e attested to the efficacy of this drug as an antihypertensi~e agent.‘-? Over the past 21/ years methyldopa (Aldome@) has been utilized in this clinic usuaily in conjunction with sulfonamide saluretic agents in the long-term treatment of hypertensive...

Maternal methyldopa treatment and neonatal blood pressure.

Enhancement of methyldopa metabolism with barbiturate.

The spurious increase in serum catecholamine levels associated with methyldopa treatment can be reduced by the simultaneous administration of phenobarbitone. This accelerating effect of phenobarbitone on methyldopa metabolism has been demonstrated in relation to both adrenaline and noradrenaline, and investigations suggest that it is due to the effect of barbiturate on the activity of metaboliz...

Methyldopa in Treatment of Severe Toxaemia of Pregnancy.

It is known that 50% N20 and 50% 02 mixture is a safe and efficient analgesic for parturient women. The British Oxygen Company have produced single cylinders of premixed gases containing a 50/50 gas and oxygen mixture, which would be ideal for use in midwifery if they could be relied upon to dispense a constant 50/50 mixture. Composition changes in premixed gas and oxygen mixtures have been rep...

Some aspects of the long-term treatment of severe hypertension with methyldopa.

EARLY reports demonstrated the value of methyldopa in the control, and short-term treatment, of hypertension (Irvine, O'Brien & North, 1962; Dollery & Harrington, 1962; Bayliss & HarveySmith, 1962), including the malignant phase (Hamilton & Kopelman, 1963). Subsequently, Johnson et al. (1966) convincingly demonstrated its value in the control of blood pressure of 100 hypertensive subjects over ...